Alcoholic liver fibrosis and the general non-specific symptoms, like alcohol. China-Japan
Friendship Hospital, 45 patients with alcoholic liver fibrosis according to the number of
symptoms and signs appear in the order as follows: 82.25 weakness, abdominal distension
66.7%, liver pain, anorexia 42.2%, 47%, 31% of limbs, numbness, memory loss and 22%,
diarrhea and sexual dysfunction was 11% each. Hepatomegaly 60%, 33% of liver palms, spider
angioma 29%, while the approval of which very little swelling.
Laboratory tests are nonspecific, but the pay is significantly increased GGT. The group
followed by GGT, triglyceride (TG) increased 60% and 58%, T BiL increased 49%, AST increased
total 42.2%, ALT increased 36%, D BiL share increased 33%, ALP 28.8% higher, while the
coagulation plasminogen activity decreased only 22%.
Iturriaga.H report (1993) GGT, and AST is a good determination of alcoholic liver injury
indicators, such as GGT> 110U, correctly forecast 80% of asymptomatic alcoholic liver
injury. Southwest Hospital Jiang Zhenghui report (1995) GGY in alcoholic liver disease in
the most characteristic expression in the alcoholic hepatitis, liver group proud to release
significantly increased GGT, alcohol quickly decreased to normal or near normal, and then
alcohol and increase in the ALT does not increase or increase is not significant.
Detection of liver fibrosis in more types of laboratory indicators, such as laminin (LN),
hyaluronic acid (HA), Ⅲ procollagen peptide (P Ⅲ P), Ⅳ collagen (Ⅳ-C) determination and
so on, each change only fibrosis of liver cells is mainly of fibrous connective tissue
extracellular matrix (ECM) synthesis and degradation. The mechanism of liver fibrosis due to
the complexity of non-current single test indicators are very sensitive and specific, the
sensitivity of each weight index and characteristics of both a certain limit, and in
patients with chronic hepatitis or cirrhosis of the liver occurs when the large overlap
Therefore, only those based on serological markers of liver fibrosis specific patient / or
diagnosis of cirrhosis or to a specific patient's anti-fibrosis markers in order to improve
diagnostic accuracy.
