Description:
Without creating a simple check of the advantages of this, but the accuracy is not high,
only as a reference and a preliminary screening and grading the degree of fibrosis, or rely
on pathological examination (liver biopsy) to determine the quantitative indicators of liver
fibrosis testing, general radioimmunoassay, the general determination of the four, it is
also referred to the liver fiber four.
Clinical significance of reference:
1, serum hyaluronic acid (HA) mainly by the liver endothelial cell uptake of decomposition,
a small amount of small molecules also increased from glomerular filtration. When the liver,
impaired renal function, serum HA increased, and increased with the disease and showed an
increasing trend. Detection of serum HA could reflect the development and outcome of hepatic
fibrosis.
2, laminin (LN), also known as laminin. A structural glycoprotein present in basement
membrane of the transparent layer. And liver fibrosis there is an important relationship is
the main basis for portal hypertension occurs. LN levels in serum are often associated with
type Ⅳ collagen, hyaluronic acid and other parallel, portal hypertension, especially in the
diagnosis of hepatic fibrosis has important value.
