Only from clinical symptoms and signs or routine laboratory tests of liver function can not
know whether there is liver fibrosis. The current method of diagnosis of liver fibrosis can
be divided into three categories:
(1) pathological diagnosis: So far, pathological examination of liver biopsy diagnosis of
liver fibrosis is still the most reliable method. By pathological examination of liver
biopsy, not only to know whether they have been developed to liver fibrosis and liver
fibrosis in the end you can find out to what extent the development, which guide clinical
treatment and prognosis helpful. Currently in clinical practice, liver biopsy equipment and
technology has a perfect system, the patient's pain is also very small, in the hands of
experienced specialists in liver disease complications are rarely serious.
(2) Diagnostic Imaging: B Chao, CT and magnetic resonance imaging and other imaging studies
can be found some signs of liver fibrosis, such as the liver contour, size, and liver
changes in signal strength in real terms. Liver blood vessel diameter and blood flow
direction, speed changes, and changes in spleen size. However, at present these imaging
studies can not yet make a diagnosis of fibrosis, more difficult to accurately determine the
severity of liver fibrosis, it is only as a secondary diagnosis.
(3) serum markers: serum indicators are currently the most widely studied method for
diagnosis of liver fibrosis, including serum type Ⅲ procollagen amino terminal propeptide
(P-Ⅲ-P), Ⅲ procollagen (PC-Ⅲ), Ⅳ collagen, hyaluronic acid (HA), laminin (1N) and so is
widely used. The level of these serum markers and liver biopsy diagnosis is closely related
to the severity of liver fibrosis, which can be used for diagnosis of liver fibrosis. After
all, as a result of liver biopsy is more direct, for a patient, it is often difficult to
target based on a laboratory level to determine the degree of liver fibrosis. But the
advantage is taken of serum tests convenient, easy to review, if you can periodically check
(eg every six months or a year) you can increase or decrease in these indicators is to
understand the general trend of development and changes in liver fibrosis can also be
broadly understanding of the clinical effects of anti-fibrosis therapy.
What is a liver biopsy Liver biopsy Liver biopsy is, simply, is to use various methods from
the patient's liver to remove one o'clock liver tissue for pathological examination.
We know that the so-called liver disease is a problem within the liver. The internal
structure of the liver cells and liver appeared abnormal. However, long in the stomach
inside the liver, we do not see it. The internal structure of the liver cells and liver, is
even more not only because of its belly across the floor can not see, but also because cells
small size, no microscope to enlarge several times, impossible to see the hundreds of times.
Although we have a variety of tests, with advanced B-, CT, MRI, etc., but all these tests
are indirect, after all, there will be many errors. As we buy a watermelon, and then
experienced person picks across the board is not as open to look at, good or bad at a
glance, is accurate.
In fact, this cut of view - to see is the biopsy. Is there a liver disease, what is the
nature of disease and severity of how to provide the most definitive answers, only through
the liver tissue under the microscope and the case of liver cells, before reaching a
conclusion. So pathological examination is the final diagnosis magistrate.
Because biopsy unparalleled irreplaceable importance, so are active in clinical biopsy to
minimize diagnostic errors, and the progress of the disease to make the most accurate
evaluation. Surgeons remove the tumor, the first cut on the operating table, the tumor is
often sent to do frozen section pathology to see the tumor is benign or malignant. During
the exam, the doctor can not leave the operating room surgery. When the pathology report on
the fastest test results, the surgery the doctor and then decide the next - step how to do
surgery. If it is benign, can be sewn on after the removal. If it is malignant, it must be
checked immediately around the tumor has not been transferred. Do lymph node dissection, and
even larger area of excision.
As for the blood system diseases, it is inseparable from the bone marrow biopsy, bone marrow
does not make a check, most of the blood disease is not diagnosed. Liver, too, only liver
biopsy can give the most accurate diagnosis. So we should vigorously carry out liver biopsy,
so that the patient, the doctor's diagnosis and to treatment, prognosis is good for.
